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In addition to its analgesic effects, oxycodone directly affects a variety of other tissues. These tissues include the medulla’s cough centre, the brain stem’s respiratory centre, the gastrointestinal tract’s muscles, the cardiovascular system, the endocrine system, the immunological system, and the pupils. Oxycodone causes dose-dependent respiratory depression in the respiratory centre. Suppression of the cough reflex is the effect on the cough centre. Students lose size or become miopic, the gastrointestinal tract’s peristalsis slows, and the colon’s muscular tone may rise, all of which contribute to constipation.

Histamine may be released in the cardiovascular system, resulting in pruritis, red eyes, flushing, perspiration, and a drop in blood pressure. Increased prolactin, decreased cortisol, and decreased testosterone are examples of endocrine consequences. The clinical significance of opioids’ effects on the immune system is still unknown.